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A short history of the drug receptor concept / Cay-R癡udiger Pr癡ull, Andreas-Holger Maehle, Robert Francis Halliwell

  • 作者： Pr癡ullCay-R癡udiger
  • 其他作者：
  • 出版： Basingstoke [England] ;New York : Palgrave Macmillan 2009
  • 叢書名： Science, technology, and medicine in modern history
  • 主題： Drug receptors--History , Receptors, Drug--history , Biomedical Research--history , History, 19th Century. , History, 20th Century. , Pharmacology--history
  • ISBN： 9780230583740 、 0230583741
  • URL： access to fulltext (Palgrave)
  • 書目註：Humans have long used plant and animal extracts for their medicinal properties but until the end of the 19th century their actions were often explained in a speculative manner. The systematic study of drugs didnot begin until the 1860s, and the concept of receptors as the target of their effects in the body only emerged at the end of the 19th century from the brilliant and independent studies of John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915). This book address the people and the key discoveries that led to the development of the receptor concept and its impact on 20th-century medicine: A.J Clark in the 1930s, andlater E.J Ariens and R.P Stephenson in the 1950s provided the quantitative basis of drug receptor occupancy theory. R.P Ahlquist's investigations gave rise to the proposal of receptor subtypes in 1948 and facilitated Sir James Black (and subsequently others) to apply the receptor concept to clinical therapy (beta blockers) in the mid 1960s. By the early 1980s, the first (acetylcholine) receptor had been isolated and cloned. Today, we recognize a large and diverse number of physiological receptors which can be delineated into 'receptor super-families' on the basis of their pharmacology and molecular properties. These receptors are now the focus of a multi-national, multi-billion dollar pharmaceutical industry. This book reveals that these successes were by no means foreseeable, since chance, coincidence, competition among scientists, and other factors played important roles in the history of the receptor concept Includes bibliographical references and index
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  • 系統號： 005162112 | 機讀編目格式

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內容註

Paul Ehrlich and his receptor concept -- The development of the concept of drug receptors in the physiological research of J.N. Langley -- The receptors and scientific pharmacology I : the critics of the receptor idea and alternative theories of drug action, c. 1905-1935 -- The receptors and scientific pharmacology II : the critics of the receptor idea and alternative research strands : the transmitter theory, c. 1905-1935 -- Quantitative arguments for the existence of drug receptors and the development of the receptor occupancy theory, c. 1910-1960 -- The dual adrenaline receptor theory of Raymond P. Ahlquist (1914-1983) and its application in drug development between 1950 and 1970 -- The emergence of molecular pharmacology

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