IGFs : local repair and survival factors throughout life span / edited by David Clemmons, Iain C.A.F. Robinson, Yves Christen
- 作者： Colloque medecine et recherche (2008 Dec. 1 : Paris, France)
- 其他作者：
- 其他題名：
- Springer eBooks
- Local repair and survival factors throughout life span
- 出版： Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg 2010
- 叢書名： Research and perspectives in endocrine interactions ,
- 主題： Somatomedin. , Insulin-like growth factor-binding proteins. , Medicine & Public Health. , Endocrinology , Human physiology. , Gene Function.
- ISBN： 9783642043024 (electronic bk.) 、 9783642043017 (paper)
- URL：
電子書
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讀者標籤：
- 系統號： 005173259 | 機讀編目格式
館藏資訊
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.