The role of model integration in complex systems modelling : an example from cancer biology / by Manish Patel, Sylvia Nagl
- 作者： Patel, Manish.
- 其他作者：
- 其他題名：
- Springer eBooks
- An example from cancer biology
- 出版： Berlin, Heidelberg : Springer Berlin Heidelberg 2010
- 叢書名： Understanding complex systems ,
- 主題： Cancer--Mathematical models. , Cancer--Research--Methodology. , Engineering. , Complexity. , Statistical Physics, Dynamical Systems and Complexity. , Systems Biology. , Cancer Research.
- ISBN： 9783642156038 (electronic bk.) 、 9783642156021 (paper)
- URL：
電子書
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讀者標籤：
- 系統號： 005177514 | 機讀編目格式
館藏資訊
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.