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Foundations of clinical research : applications to practice / Leslie G. Portney, Mary P. Watkins

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pt. I. Foundations of clinical research. A concept of clinical research -- The role of theory in clinical research -- Ethical issues in clinical research -- pt. II. Concepts of measurement. Principles of measurement -- Reliability of measurements -- Validity of measurements -- pt. III. Designing clinical research. Asking the research question -- Sampling -- Validity in experimental design -- Experimental designs -- Quasi-experimental designs -- Single subject designs -- Exploratory research: observational designs -- Descriptive research -- Surveys and questionnaires -- Systematic reviews and meta-analysis -- pt. IV. Data analysis. Descriptive statistics -- Statistical inference -- Comparing two means: the t-test -- Comparing more than two means: analysis of variance -- Multiple comparison tests -- Nonparametric tests for group comparisons -- Correlation -- Regression -- Measures of association for categorical variables: chi-square -- Statistical measures of reliability -- Statistical measures of validity -- Epidemiology: measures of risk -- Multivariate analysis -- Data management -- pt. V. Communication. Searching the literature -- Writing a research proposal -- Reporting the results of clinical research -- Evaluating research reports -- Appendices : A. Statistical tables -- B. Relating the research question to the choice of statistical test -- C. Power and sample size -- D. Transformation of data -- E. Sample informed consent form

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