Affinity and efficacy [electronic resource] : the components of drug-receptor interactions / Frederick J. Ehlert
- 作者： Ehlert, Frederick J.
- 出版： New Jersey : World Scientific 2014
- 主題： Drug receptors , Drugs--Effectiveness , Drug-nutrient interactions. , Pharmaceutical chemistry. , Receptors, Drug , Ligand-Gated Ion Channels , Protein binding. , Radioligand Assay , Receptors, G-Protein-Coupled
- ISBN： 9789814324229 (electronic bk.) 、 9814324221 (electronic bk.)
- URL：
電子書
- 一般註：Print version record
- 書目註：Includes bibliographical references
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讀者標籤：
- 系統號： 005223905 | 機讀編目格式
館藏資訊
內容註
Ligand-gated ion channels -- Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- Competitive interactions between orthostheric ligands at ligand-gated ion channels -- Analysis of allosteric interactions at ligand-gated ion channels -- G protein-coupled receptors and G protein signaling -- Affinity and efficacy of the agonist-receptor-G-protein interaction -- Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- Analysis of ligand bias in receptor signaling through different G protein pathways -- Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- Analysis of allosterism in functional assays on G protein-coupled receptors -- Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors