The comprehensive sourcebook of bacterial protein toxins [electronic resource] / [edited by] Joseph E. Alouf, Daniel Ladant, Michel R. Popoff.
- 其他作者：
- 其他題名：
- Bacterial protein toxins
- 出版： Amsterdam : Academic Press c2015.
- 主題： Bacterial toxins. , Bacterial toxins. , Bacterial proteins
- 版本：4th ed.
- ISBN： 9780128005897 (electronic bk.) 、 0128005890 (electronic bk.) 、 9780128001882 (electronic bk.)
- URL：
click for full text
- 書目註：Includes bibliographical references and index.
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讀者標籤：
- 系統號： 005235644 | 機讀編目格式
館藏資訊
摘要註
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial proteintoxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.
內容註
Ch. 1. A 116-year story of bacterial protein toxins (1888-2004): from "diphtheritic poison" to molecular toxinology Ch. 2. Evolutionary aspects of toxin-producing bacteria Ch. 3. Mobile genetic elements and pathogenicity islands encoding bacterial toxins Ch. 4. Regulation systems of toxin expression Ch. 5. Toxin secretion systems Ch. 6. Toxin receptors Ch. 7. Translocation of bacterial protein toxin into the cytosol Ch. 8. Intracellular trafficking of bacterial and plant protein toxins Ch. 9. Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular Ch. 10. Bacterial toxins and mitochondria Ch. 11. Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries Ch. 12. Molecular, functional, and evolutionary aspects of ADP-ribosylating toxins Ch. 13. Diphtheria toxin Ch. 14. Pseudomonas aeruginosa toxins Ch. 15. Vibrio cholerae and Escherichia coli thermolabile enterotoxin Ch. 16. Bordetella protein toxins Ch. 17. The Shiga toxins: properties and action on cells Ch. 18. Bacillus anthracis toxins Ch. 19. Attack of the nervous system by clostridial toxins: physical findings, cellular and molecular actions Ch. 20. Uptake and transport of clostridium neurotoxins Ch. 21. Large clostridial cytotoxins modifying small GTPases Ch. 22. Pasteurella multocida toxin Ch. 23. Cytolethal distending toxins Ch. 24. Helicobacter pylori vacuolating toxin Ch. 25. Escherichia coli heat-stable enterotoxin b Ch. 26. Paradigms and classification of bacterial membrane-damaging toxins Ch. 27. . Membrane-damaging and cytotoxic phospholipases Ch. 28. Bacteroidesfragilis toxins Ch. 29. Structure and mode of action of RTX toxins