Mechanisms of DNA recombination and genome rearrangements. Methods to study homologous recombination / edited by Maria Spies, Anna Malkova
- 其他作者：
- 其他題名：
- Methods to study homologous recombination
- 出版： Cambridge, MA : Academic Press is an imprint of Elsevier 2018
- 叢書名： Methods in enzymology ,v. 600
- 主題： Homologous Recombination , DNA, Recombinant , Recombinant Proteins--analysis , Genome--physiology
- ISBN： 9780128144299 (hbk.) :: US$199.00 、 0128144297 (hbk.)
- 一般註：Includes bibliographical references
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讀者標籤：
- 系統號： 005257524 | 機讀編目格式
館藏資訊
Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.