Design and analysis of pragmatic trials / Song Zhang, Chul Ahn, and Hong Zhu.
- 作者： Zhang, Song, 1976-
- 其他作者：
- 其他題名：
- Chapman & Hall/CRC biostatistics series.
- 出版： Boca Raton, FL : CRC Press 2023.
- 叢書名： Chapman & Hall/CRC biostatistics series
- 主題： Clinical trials--Statistical methods. , Cluster analysis. , Generalized estimating equations. , Clinical Trials as Topic--methods , Cluster Analysis , Models, Statistical
- 版本：1st ed.
- ISBN： 9780367627355 (hbk.) :: GBP94.99 、 9780367647360 (pbk.)
- 書目註：Includes bibliographical references and index.
-
讀者標籤：
- 系統號： 005302069 | 機讀編目格式
館藏資訊
摘要註
"This book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that need to be addressed by statisticians at the design stage. It discusses the advantages and disadvantages of each type of PCT, and provides sample size formulas, sensitivity analyses, and examples for sample size calculation. The generalized estimating equation (GEE) method will be employed to derive sample size formulas for various types of outcomes from the exponential family, including continuous, binary, and count variables. Experimental designs that have been frequently employed in PCTs will be discussed, including cluster randomized designs, matched-pair cluster randomized design, stratified cluster randomized design, stepped-wedge cluster randomized design, longitudinal cluster randomized design, and crossover cluster randomized design. It demonstrates that the GEE approach is flexible to accommodate pragmatic issues such as hierarchical correlation structures, different missing data patterns, randomly varying cluster sizes, etc. It has been reported that the GEE approach leads to under-estimated variance with limited numbers of clusters. The remedy for this limitation is investigated for the design of PCTs. This book can assist practitioners in the design of PCTs by providing a description of the advantages and disadvantages of various PCTs and sample size formulas that address various pragmatic issues, facilitating the proper implementation of PCTs to improve health care. It can also serve as a textbook for biostatistics students at the graduate level to enhance their knowledge or skill in clinical trial design"--
內容註
Pragmatic randomized trials -- Cluster randomized trials -- Matched-pair cluster randomized design for pragmatic studies -- Stratified cluster randomized design for pragmatic studies -- The gee approach for stepped-wedge trial design -- The mixed-effect model approach and adaptive strategies for stepped-wedge trial design.